Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the National Cancer Institute|
|State||Published - Dec 1 1975|
ASJC Scopus subject areas
- Cancer Research