Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides

J. D. Scribner, T. J. Slaga

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.

Original languageEnglish (US)
Pages (from-to)491-493
Number of pages3
JournalJournal of the National Cancer Institute
Volume54
Issue number2
StatePublished - Dec 1 1975
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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