Abstract
Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-493 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 54 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides. / Scribner, J. D.; Slaga, Thomas J.
In: Journal of the National Cancer Institute, Vol. 54, No. 2, 1975, p. 491-493.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides
AU - Scribner, J. D.
AU - Slaga, Thomas J
PY - 1975
Y1 - 1975
N2 - Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
AB - Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016668473&partnerID=8YFLogxK
M3 - Article
C2 - 1113329
AN - SCOPUS:0016668473
VL - 54
SP - 491
EP - 493
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 2
ER -