Abstract
Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-493 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 54 |
| Issue number | 2 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Scribner, J. D., & Slaga, T. J. (1975). Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides. Journal of the National Cancer Institute, 54(2), 491-493.