Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides

J. D. Scribner, Thomas J Slaga

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Four N acetoxy N arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N acetoxy 2 acetamidophenanthrene > N acetoxy 4 acetamidostilbene N acetoxy 2 acetamidofluorene > N acetoxy 4 acetamidobiphenyl. Two substituted N benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.

Original languageEnglish (US)
Pages (from-to)491-493
Number of pages3
JournalJournal of the National Cancer Institute
Volume54
Issue number2
StatePublished - 1975
Externally publishedYes

Fingerprint

2-Acetylaminofluorene
Skin
Methanol
Neoplasms
Carcinogenesis
Ions
piperidine
2-acetamidophenanthrene
N-acetoxy-4-acetylaminostilbene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tumor initiation by N acyloxy derivatives of piperidine and N arylacetamides. / Scribner, J. D.; Slaga, Thomas J.

In: Journal of the National Cancer Institute, Vol. 54, No. 2, 1975, p. 491-493.

Research output: Contribution to journalArticle

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