Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice

Stephen Nesnow, Larry L. Triplett, Thomas J Slaga

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (>99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks of promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Systemic administration of 1-nitropyrene by i.p. injection over a dose range of 0-8.0 mg/mouse followed by topical treatment with TPA also did not induce papilloma formation. A mixture of dinitropyrenes (1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene (1:1.94:1.95)) (99% purity) was dermally applied to SENCAR mice over a dose range of 0-2.0 mg/mouse and the mice subsequently promoted with TPA. A significant induction of papillomas was observed at 30 weeks (0.37-0.39 papillomas/mouse, 26-29% of the mice bearing tumors) at 2.0 mg/mouse. Comparison of this data with that obtained from the same mouse strain using diesel exhaust particulate extracts containing 1-nitropyrene and its nitrated products indicate that these nitrated polynuclear aromatics do not significantly contribute to the mouse skin tumorigenic activity of diesel exhaust particulate extracts.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCancer Letters
Volume23
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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1-nitropyrene
Inbred SENCAR Mouse
Papilloma
Neoplasms
Tetradecanoylphorbol Acetate
Vehicle Emissions
Skin
Mutagens

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice. / Nesnow, Stephen; Triplett, Larry L.; Slaga, Thomas J.

In: Cancer Letters, Vol. 23, No. 1, 1984, p. 1-8.

Research output: Contribution to journalArticle

Nesnow, Stephen ; Triplett, Larry L. ; Slaga, Thomas J. / Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice. In: Cancer Letters. 1984 ; Vol. 23, No. 1. pp. 1-8.
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abstract = "The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (>99.5{\%} purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks of promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Systemic administration of 1-nitropyrene by i.p. injection over a dose range of 0-8.0 mg/mouse followed by topical treatment with TPA also did not induce papilloma formation. A mixture of dinitropyrenes (1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene (1:1.94:1.95)) (99{\%} purity) was dermally applied to SENCAR mice over a dose range of 0-2.0 mg/mouse and the mice subsequently promoted with TPA. A significant induction of papillomas was observed at 30 weeks (0.37-0.39 papillomas/mouse, 26-29{\%} of the mice bearing tumors) at 2.0 mg/mouse. Comparison of this data with that obtained from the same mouse strain using diesel exhaust particulate extracts containing 1-nitropyrene and its nitrated products indicate that these nitrated polynuclear aromatics do not significantly contribute to the mouse skin tumorigenic activity of diesel exhaust particulate extracts.",
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