Tumor Immunology, Autoimmunity and Aging

EDMOND J. YUNIS, GABRIEL FERNANDES, LEONARD J. GREENBERG

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

ABSTRACT: Cell‐mediated immune function declines with aging, and may be associated with autoimmunity and malignancy. Humoral immune responses also decline with aging. The chief age‐related effect on the immune system is a decrease in T‐cell function. The “thymus clock” and immunogenesis are discussed in relation to aging. In animals, attempts at immunologic rejuvenation by cellular or hormonal means have not been as successful as the results attained by genetic manipulation. 1976 The American Geriatrics Society

Original languageEnglish (US)
Pages (from-to)258-263
Number of pages6
JournalJournal of the American Geriatrics Society
Volume24
Issue number6
DOIs
StatePublished - Jun 1976

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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