Tumor-associated antigens in breast carcinomas. Prognostic significance

C. Cohen, Francis E Sharkey, G. Shulman, E. O. Uthman, L. R. Budgeon

Research output: Contribution to journalArticle

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Abstract

In an attempt to identify biologic markers that might predict prognosis in breast cancer patients, the presence or absence of seven tumor-associated antigens in 54 infiltrating breast carcinomas was correlated with tumor recurrence rates (minimum five-year follow-up), axillary lymph node metastases and tumor volume. Immunohistochemical kappa-casein was present in 30 (56%) tumors, alpha-lactalbumin in 39 (72%) tumors, secretory component of IgA in 26 (48%) tumors, carcinoembryonic antigen in 34 (63%) tumors, pregnancy-specific beta-1-glycoprotein in 7 (13%) tumors, beta subunit of human chorionic gonadotrphin in 1 (2%) tumor and human placental lactogen in 0 (0%) tumors. There was no significant correlation between the presence or absence in tumor of any of the antigens, and prognosis as assessed either by 5-year recurrence rates (P > 0.18) or by the presence of axillary lymph node metastases (P > 0.20). No significant difference was noted in mean tumor volume (cm3) ± SEM, between tumors with or without antigen immunoreactivity (P > 0.05).

Original languageEnglish (US)
Pages (from-to)1294-1298
Number of pages5
JournalCancer
Volume60
Issue number6
StatePublished - 1987
Externally publishedYes

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Neoplasm Antigens
Breast Neoplasms
Neoplasms
Tumor Burden
Lymph Nodes
Neoplasm Metastasis
Secretory Component
Placental Lactogen
Lactalbumin
Recurrence
Secretory Immunoglobulin A
Carcinoembryonic Antigen
Caseins
Biomarkers
Antigens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cohen, C., Sharkey, F. E., Shulman, G., Uthman, E. O., & Budgeon, L. R. (1987). Tumor-associated antigens in breast carcinomas. Prognostic significance. Cancer, 60(6), 1294-1298.

Tumor-associated antigens in breast carcinomas. Prognostic significance. / Cohen, C.; Sharkey, Francis E; Shulman, G.; Uthman, E. O.; Budgeon, L. R.

In: Cancer, Vol. 60, No. 6, 1987, p. 1294-1298.

Research output: Contribution to journalArticle

Cohen, C, Sharkey, FE, Shulman, G, Uthman, EO & Budgeon, LR 1987, 'Tumor-associated antigens in breast carcinomas. Prognostic significance', Cancer, vol. 60, no. 6, pp. 1294-1298.
Cohen C, Sharkey FE, Shulman G, Uthman EO, Budgeon LR. Tumor-associated antigens in breast carcinomas. Prognostic significance. Cancer. 1987;60(6):1294-1298.
Cohen, C. ; Sharkey, Francis E ; Shulman, G. ; Uthman, E. O. ; Budgeon, L. R. / Tumor-associated antigens in breast carcinomas. Prognostic significance. In: Cancer. 1987 ; Vol. 60, No. 6. pp. 1294-1298.
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