TY - JOUR
T1 - TSPAN33 is a novel marker of activated and malignant B cells
AU - Luu, Van Phi
AU - Hevezi, Peter
AU - Vences-Catalan, Felipe
AU - Maravillas-Montero, José Luis
AU - White, Clayton Alexander
AU - Casali, Paolo
AU - Llorente, Luis
AU - Jakez-Ocampo, Juan
AU - Lima, Guadalupe
AU - Vilches-Cisneros, Natalia
AU - Flores-Gutiérrez, Juan Pablo
AU - Santos-Argumedo, Leopoldo
AU - Zlotnik, Albert
N1 - Funding Information:
We thank David Fruman for his kind gift of B cell lymphoma lines. We also thank Janette Furuzawa-Carballeda and Carlos A Rodríguez-Osorio for their help with the human lupus samples. This work was funded in part by NSF IGERT LifeChips award # DGE-0549479 , a collaborative grant from UCMEXUS , and an NIH NIAID grant R21096278 (to AZ).
PY - 2013/12
Y1 - 2013/12
N2 - We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
AB - We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
KW - B cells
KW - Biomarker
KW - Lupus erythematosus
KW - Lymphoma
KW - Rheumatoid arthritis
KW - Tetraspanin 33
UR - https://www.scopus.com/pages/publications/84887188377
UR - https://www.scopus.com/pages/publications/84887188377#tab=citedBy
U2 - 10.1016/j.clim.2013.08.005
DO - 10.1016/j.clim.2013.08.005
M3 - Article
C2 - 24211713
AN - SCOPUS:84887188377
SN - 1521-6616
VL - 149
SP - 388
EP - 399
JO - Clinical Immunology
JF - Clinical Immunology
IS - 3 PB
ER -