TSPAN33 is a novel marker of activated and malignant B cells

Van Phi Luu, Peter Hevezi, Felipe Vences-Catalan, José Luis Maravillas-Montero, Clayton Alexander White, Paolo Casali, Luis Llorente, Juan Jakez-Ocampo, Guadalupe Lima, Natalia Vilches-Cisneros, Juan Pablo Flores-Gutiérrez, Leopoldo Santos-Argumedo, Albert Zlotnik

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)388-399
Number of pages12
JournalClinical Immunology
Issue number3 PB
StatePublished - Dec 2013
Externally publishedYes


  • B cells
  • Biomarker
  • Lupus erythematosus
  • Lymphoma
  • Rheumatoid arthritis
  • Tetraspanin 33

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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