Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove

Sergio D. Paredes, Ma Pilar Terrón, Javier Cubero, Vicente Valero, Carmen Barriga, Russel J Reiter, Ana B. Rodríguez

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The sleep promoting functions of melatonin have gained wide scientific attention due to the ability of this indole to provide relief from sleep inefficiency and the temporal relationship between its nocturnal rise in the blood and the "opening of the sleep gate" at night. However, little is known about the effects exerted by its precursor, the amino acid tryptophan. We studied the effect of a 7-day administration of two concentrations of tryptophan (125 and 300 kg b.w.) on the activity/rest rhythms of ringdove, aged 2-3 (young) and 10-12 (old) years, and on the serum levels of serotonin and melatonin. Activity pulses were logged before, during, and up to 5 days after the treatments. The animals received 125 or 300 mg/kg b.w. per animal/day at 09:00 h or at 19:00 h. Subsequently we chose the treatment which gave the best results in terms of nocturnal rest without affecting diurnal activity, i.e., 300 mg/kg b.w. administered to old animals at 09:00 h, 1 h after lights on, for the serotonin and melatonin measurements. During this treatment, the nocturnal and diurnal levels and amplitudes of serotonin and melatonin were all significantly higher than the corresponding levels before and after the treatment. In sum, our results point to an improvement of nocturnal rest in this animal model of old ringdove when administering 300 mg/kg tryptophan 1 h after lights on.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalPhysiology and Behavior
Volume90
Issue number4
DOIs
StatePublished - Mar 16 2007

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Melatonin
Tryptophan
Serotonin
Sleep
Serum
Light
Aptitude
Therapeutics
Animal Models
Amino Acids

Keywords

  • Activity/rest rhythms
  • Age
  • Melatonin
  • Serotonin
  • Tryptophan

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove. / Paredes, Sergio D.; Terrón, Ma Pilar; Cubero, Javier; Valero, Vicente; Barriga, Carmen; Reiter, Russel J; Rodríguez, Ana B.

In: Physiology and Behavior, Vol. 90, No. 4, 16.03.2007, p. 576-582.

Research output: Contribution to journalArticle

Paredes, Sergio D. ; Terrón, Ma Pilar ; Cubero, Javier ; Valero, Vicente ; Barriga, Carmen ; Reiter, Russel J ; Rodríguez, Ana B. / Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove. In: Physiology and Behavior. 2007 ; Vol. 90, No. 4. pp. 576-582.
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