Tryptophan depletion and attenuation of cue-induced craving for cocaine

Sally L. Satel, John H. Krystal, Pedro L. Delgado, Thomas R. Kosten, Dennis S. Charney

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Objective: Although cocaine is a potent serotonin (5-HT) reuptake blocker, the role of S-HT systems in cocaine craving and relapse in humans has been unclear. The authors evaluated whether acute reductions in central 5-HT synthesis modulated craving for cocaine in cocaine-dependent patients. Method: Twenty-five cocaine-dependent male inpatients were exposed to cocaine-craving cues while their 5-HT levels were lowered and during a placebo condition in a counterbalanced, double-blind design. 5-HT levels were reduced by rapidly lowering plasma levels of its precursor, tryptophan; tryptophan levels were reduced by stimulating protein synthesis with a large drink of amino acids devoid of tryptophan. During the placebo condition the patients drank an identical amino acid drink containing tryptophan. Craving was induced by exposing patients to cocaine paraphernalia and a videotape depicting drug use. Craving was assessed 7 hours after ingestion of the drink. Visual analog ratings of craving for cocaine were administered before and after cue exposure at each test session. Results: Patients reported less desire for cocaine stimulated by cue exposure after drinking amino acids without tryptophan than they did after drinking placebo. The order that tryptophan depletion and placebo tests were performed influenced the impact of tryptophan depletion on cue-induced craving. Conclusions: Serotonergic systems modulate cue-induced craving for cocaine, a factor implicated in relapse to cocaine use.

Original languageEnglish (US)
Pages (from-to)778-783
Number of pages6
JournalAmerican Journal of Psychiatry
Volume152
Issue number5
StatePublished - May 1995
Externally publishedYes

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Cocaine
Tryptophan
Cues
Serotonin
Placebos
Amino Acids
Drinking
Craving
Recurrence
Videotape Recording
Inpatients
Eating

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Satel, S. L., Krystal, J. H., Delgado, P. L., Kosten, T. R., & Charney, D. S. (1995). Tryptophan depletion and attenuation of cue-induced craving for cocaine. American Journal of Psychiatry, 152(5), 778-783.

Tryptophan depletion and attenuation of cue-induced craving for cocaine. / Satel, Sally L.; Krystal, John H.; Delgado, Pedro L.; Kosten, Thomas R.; Charney, Dennis S.

In: American Journal of Psychiatry, Vol. 152, No. 5, 05.1995, p. 778-783.

Research output: Contribution to journalArticle

Satel, SL, Krystal, JH, Delgado, PL, Kosten, TR & Charney, DS 1995, 'Tryptophan depletion and attenuation of cue-induced craving for cocaine', American Journal of Psychiatry, vol. 152, no. 5, pp. 778-783.
Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. American Journal of Psychiatry. 1995 May;152(5):778-783.
Satel, Sally L. ; Krystal, John H. ; Delgado, Pedro L. ; Kosten, Thomas R. ; Charney, Dennis S. / Tryptophan depletion and attenuation of cue-induced craving for cocaine. In: American Journal of Psychiatry. 1995 ; Vol. 152, No. 5. pp. 778-783.
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