TRPC channels and Parkinson’s disease

Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj, Brij B Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Parkinson’s disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson’s disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling. Importantly, though disturbances in Ca2+ homeostasis have been implicated in Parkinson’s disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of Ca2+ channels, and it could be anticipated that these channels could play important roles in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused on TRPC channels and elucidated its role in PD.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages85-94
Number of pages10
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume976
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Calcium signaling
  • Dopaminergic neurons
  • ER stress
  • Oxidative stress
  • Parkinson’s disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Sukumaran, P., Sun, Y., Schaar, A., Selvaraj, S., & Singh, B. B. (2017). TRPC channels and Parkinson’s disease. In Advances in Experimental Medicine and Biology (pp. 85-94). (Advances in Experimental Medicine and Biology; Vol. 976). Springer New York LLC. https://doi.org/10.1007/978-94-024-1088-4_8