Trophoblastic giant cells of the mouse placenta contain calbindin-D(9k) but not the vitamin D receptor

D. R. Shamley, G. Veale, J. M. Pettifor, R. Buffenstein

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of vitamin D deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor (VDR) in the placenta and yolk sac of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of CaBP-D(9k) (9 kDa) in the yolk sac endoderm or trophoblastic giant cells (TGCs) of the placenta. VDRs were undetectable in TGCs and yolk sac endoderm, but were present in the intraplacental yolk sac. Since yolk sac endoderm and TGCs contain CaBP but not VDR, it is unlikely that CaBP synthesis and/or activity in these cells is controlled by vitamin D. The TGCs, therefore, may be involved in vitamin D-independent transplacental transfer of calcium.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalJournal of Endocrinology
Volume150
Issue number1
StatePublished - Jul 1996
Externally publishedYes

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Calbindins
Yolk Sac
Calcitriol Receptors
Giant Cells
Calcium-Binding Proteins
Placenta
Endoderm
Vitamin D
Vitamin D Deficiency
Mothers
Calcium

ASJC Scopus subject areas

  • Endocrinology

Cite this

Shamley, D. R., Veale, G., Pettifor, J. M., & Buffenstein, R. (1996). Trophoblastic giant cells of the mouse placenta contain calbindin-D(9k) but not the vitamin D receptor. Journal of Endocrinology, 150(1), 25-32.

Trophoblastic giant cells of the mouse placenta contain calbindin-D(9k) but not the vitamin D receptor. / Shamley, D. R.; Veale, G.; Pettifor, J. M.; Buffenstein, R.

In: Journal of Endocrinology, Vol. 150, No. 1, 07.1996, p. 25-32.

Research output: Contribution to journalArticle

Shamley, DR, Veale, G, Pettifor, JM & Buffenstein, R 1996, 'Trophoblastic giant cells of the mouse placenta contain calbindin-D(9k) but not the vitamin D receptor', Journal of Endocrinology, vol. 150, no. 1, pp. 25-32.
Shamley, D. R. ; Veale, G. ; Pettifor, J. M. ; Buffenstein, R. / Trophoblastic giant cells of the mouse placenta contain calbindin-D(9k) but not the vitamin D receptor. In: Journal of Endocrinology. 1996 ; Vol. 150, No. 1. pp. 25-32.
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