Trophoblast stem cells: Models for investigating trophectoderm differentiation and placental development

Gordon C. Douglas, Catherine A. VandeVoort, Priyadarsini Kumar, Tiencheng A Chang, Thaddeus G. Golos

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The placenta is an ephemeral organ containing diverse populations of trophoblasts that are all derived from the embryonic trophectoderm but have morphological, functional, and molecular diversity within and across species. In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua. Within the rapidly growing placenta, it has been shown that there are trophoblast stem cells well characterized in the mouse and postulated but not well understood in primates. This review will discuss the characteristics of candidates for human and nonhuman primate trophoblast stem cells, present the diverse methods of their generation, and propose future prospects for experimental systems in which they can shed light on developmental and pathophysiological processes in human pregnancy.

Original languageEnglish (US)
Pages (from-to)228-240
Number of pages13
JournalEndocrine Reviews
Volume30
Issue number3
DOIs
StatePublished - May 2009
Externally publishedYes

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Placentation
Trophoblasts
Stem Cells
Placenta
Primates
Decidua
Social Responsibility
Mothers
Pregnancy
Population

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Trophoblast stem cells : Models for investigating trophectoderm differentiation and placental development. / Douglas, Gordon C.; VandeVoort, Catherine A.; Kumar, Priyadarsini; Chang, Tiencheng A; Golos, Thaddeus G.

In: Endocrine Reviews, Vol. 30, No. 3, 05.2009, p. 228-240.

Research output: Contribution to journalArticle

Douglas, Gordon C. ; VandeVoort, Catherine A. ; Kumar, Priyadarsini ; Chang, Tiencheng A ; Golos, Thaddeus G. / Trophoblast stem cells : Models for investigating trophectoderm differentiation and placental development. In: Endocrine Reviews. 2009 ; Vol. 30, No. 3. pp. 228-240.
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