TY - JOUR
T1 - Trophoblast stem cells
T2 - Models for investigating trophectoderm differentiation and placental development
AU - Douglas, Gordon C.
AU - VandeVoort, Catherine A.
AU - Kumar, Priyadarsini
AU - Chang, Tien Cheng
AU - Golos, Thaddeus G.
PY - 2009/5
Y1 - 2009/5
N2 - The placenta is an ephemeral organ containing diverse populations of trophoblasts that are all derived from the embryonic trophectoderm but have morphological, functional, and molecular diversity within and across species. In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua. Within the rapidly growing placenta, it has been shown that there are trophoblast stem cells well characterized in the mouse and postulated but not well understood in primates. This review will discuss the characteristics of candidates for human and nonhuman primate trophoblast stem cells, present the diverse methods of their generation, and propose future prospects for experimental systems in which they can shed light on developmental and pathophysiological processes in human pregnancy.
AB - The placenta is an ephemeral organ containing diverse populations of trophoblasts that are all derived from the embryonic trophectoderm but have morphological, functional, and molecular diversity within and across species. In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua. Within the rapidly growing placenta, it has been shown that there are trophoblast stem cells well characterized in the mouse and postulated but not well understood in primates. This review will discuss the characteristics of candidates for human and nonhuman primate trophoblast stem cells, present the diverse methods of their generation, and propose future prospects for experimental systems in which they can shed light on developmental and pathophysiological processes in human pregnancy.
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U2 - 10.1210/er.2009-0001
DO - 10.1210/er.2009-0001
M3 - Review article
C2 - 19299251
AN - SCOPUS:65649154702
SN - 0163-769X
VL - 30
SP - 228
EP - 240
JO - Endocrine Reviews
JF - Endocrine Reviews
IS - 3
ER -