Trisomy 8p: unusual origin detected by fluorescence in situ hybridization

Charleen M. Moore, Katrina Barnum, Celia I. Kaye, Kathleen S. Kagan-Hallett, Jan C. Liang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chromosomal analysis of a neonate with brain and heart abnormalities revealed trisomy for 8p. The mother's karyotype showed 47 chromosomes with one chromosome 8 being represented as two separate chromosomes, an acrocentric 8p and a telocentric 8q. Gbanding and silver staining revealed a satellite and nucleolus organizing region (NOR) on the 8p. Centromericspecific probes to the centromeres of chromosomes 8, 15, 13/21, 22 and the acrocentric chromosomes revealed that only the 8q centromere was of chromosome-8 origin, while the 8p centromere was of chromosome-14 origin.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalHuman Genetics
Volume89
Issue number3
DOIs
StatePublished - May 1 1992

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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