Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

Gregory M. Anstead, Hung Kuei Lin, Glenn D. Prestwich

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - Jun 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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