Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

Gregory M Anstead, Hung Kuei Lin, Glenn D. Prestwich

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Hydroxylamine
Biosynthesis
Sterols
Enzymes
squalene epoxidase-cyclase
lanosterol synthase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Trisnorsqualene methyl hydroxylamine : a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase. / Anstead, Gregory M; Lin, Hung Kuei; Prestwich, Glenn D.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 6, 1993, p. 1319-1322.

Research output: Contribution to journalArticle

@article{5a6c04e32ca54be5b7744848cb338622,
title = "Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase",
abstract = "Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.",
author = "Anstead, {Gregory M} and Lin, {Hung Kuei} and Prestwich, {Glenn D.}",
year = "1993",
doi = "10.1016/S0960-894X(00)80339-X",
language = "English (US)",
volume = "3",
pages = "1319--1322",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Trisnorsqualene methyl hydroxylamine

T2 - a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

AU - Anstead, Gregory M

AU - Lin, Hung Kuei

AU - Prestwich, Glenn D.

PY - 1993

Y1 - 1993

N2 - Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

AB - Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

UR - http://www.scopus.com/inward/record.url?scp=0027295112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027295112&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)80339-X

DO - 10.1016/S0960-894X(00)80339-X

M3 - Article

AN - SCOPUS:0027295112

VL - 3

SP - 1319

EP - 1322

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 6

ER -