Triple agent immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome

Mamta Agarwal, Sudha K. Ganesh, Jyotirmay Biswas

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Purpose: To describe the role of triple agent immunosuppression in severe recalcitrant cases of Vogt-Koyanagi-Harada syndrome. Materials and methods: Retrospective chart review of five cases of Vogt-Koyanagi-Harada syndrome. Results: All cases were treated with oral prednisolone, azathioprine, and cyclosporine in combination, and rapid remission was observed in all patients. The synergistic effect of the triple agent immunosuppressives helped in preventing recurrences. Prolonged treatment with steroid sparing immunosuppressives in severe and recalcitrant cases of Vogt-Koyanagi-Harada syndrome maintained disease remission. Conclusion: Severe cases of Vogt-Koyanagi-Harada syndrome can be treated with early use of high-dose triple agent immunosuppressives.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalOcular Immunology and Inflammation
Volume14
Issue number6
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Keywords

  • Riple agent immunosuppression
  • VKH

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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