Triiodothyronine exerts a major pleiotropic effect on reverse cholesterol transport phenotypes

Anthony G. Comuzzie, J. Blangero, Michael C. Mahaney, R. Mark Sharp, John L. Vandeberg, Michael P. Stern, Jean W. MacCluer

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations


    The thyroid hormone triiodothyronine (T3) is known to be a potent mediator of APOA1 gene expression. With the use of multivariate quantitative genetic analysis, we have assessed the magnitude of shared effects of T3 on plasma concentrations of apolipoprotein AI (apo AI) and three related phenotypes: HDL-C, apo AII, and LpAI (which is a concentration of apo AI that contains HDL particles). Maximum likelihood techniques were used to simultaneously estimate mean effects and variance components in large, extended Mexican American families living in San Antonio, Tex. We found that T3 accounted for 16%, 23%, 21%, and 37% of the additive genetic variance in HDL-C, apo AI, apo AII, and LpAI, respectively, while explaining virtually none of the random environmental variance in these phenotypes. T3 also has a pronounced effect on the pairwise genetic correlations among the four phenotypes: After the pleiotropic effects of T3 concentrations are controlled for, the genetic correlations are reduced by 6% in the case of HDL-C and apo AI and 97% for apo AII and LpAI. Thus, genes that influence T3 have a significant effect on HDL-C, apo AI, apo AII, and LpAI and also on the correlations among these phenotypes.

    Original languageEnglish (US)
    Pages (from-to)289-293
    Number of pages5
    JournalArteriosclerosis, Thrombosis, and Vascular Biology
    Issue number2
    StatePublished - 1996


    • HDL-C
    • LpAI
    • apo AI
    • apo AII
    • thyroid hormones

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


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