Trends in use of high-risk medications for older veterans

2004 to 2006

Mary Jo V Pugh, Joseph T. Hanlon, Chen-pin Wang, Todd Semla, Muriel Burk, Megan E. Amuan, Ashlei Lowery, Chester B. Good, Dan R. Berlowitz

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES: To examine the change in use of high-risk medications for the elderly (HRME), as defined by the National Committee on Quality Assurance's Healthcare Effectiveness Data and Information Set (HEDIS) quality measure (HEDIS HRME), by older outpatient veterans over a 3-year period and to identify risk factors for HEDIS HRME exposure overall and for the most commonly used drug classes. DESIGN: Longitudinal retrospective database analysis. SETTING: Outpatient clinics within the Department of Veterans Affairs (VA). PARTICIPANTS: Veterans aged 65 by October 1, 2003, and who received VA care at least once each year until September 30, 2006. MEASUREMENTS: Rates of use of HEDIS HRME overall and according to specific drug classes each year from fiscal year 2004 (FY04) to FY06. RESULTS: In a cohort of 1,567,467, high-risk medication exposure fell from 13.1% to 12.3% between FY04 and FY06 (P<.001). High-risk antihistamines (e.g., diphenhydramine), opioid analgesics (e.g., propoxyphene), skeletal muscle relaxants (e.g., cyclobenzaprine), psychotropics (e.g., long half-life benzodiazepines), endocrine (e.g., estrogen), and cardiac medications (e.g., short-acting nifedipine) had modest but statistically significant (P<.001) reductions (range -3.8% to -16.0%); nitrofurantoin demonstrated a statistically significant increase (+36.5%; P<.001). Overall HEDIS HRME exposure was more likely for men, Hispanics, those receiving more medications, those with psychiatric comorbidity, and those without prior geriatric care. Exposure was lower for individuals exempt from copayment. Similar associations were seen between ethnicity, polypharmacy, psychiatric comorbidity, access-to-care factors, and use of individual HEDIS HRME classes. CONCLUSION: HEDIS HRME drug exposure decreased slightly in an integrated healthcare system. Risk factors for exposure were not consistent across drug groups. Future studies should examine whether interventions to further reduce HEDIS HRME use improve health outcomes.

Original languageEnglish (US)
Pages (from-to)1891-1898
Number of pages8
JournalJournal of the American Geriatrics Society
Volume59
Issue number10
DOIs
StatePublished - Oct 2011

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Veterans
Estrogens
Delivery of Health Care
Pharmaceutical Preparations
Psychiatry
Comorbidity
Health Care Quality Assurance
Neuromuscular Agents
Dextropropoxyphene
Nitrofurantoin
Diphenhydramine
Polypharmacy
Datasets
Quality of Health Care
Histamine Antagonists
Nifedipine
Ambulatory Care Facilities
Benzodiazepines
Hispanic Americans
Geriatrics

Keywords

  • aged
  • inappropriate prescribing
  • pharmacoepidemiology
  • quality of care

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Pugh, M. J. V., Hanlon, J. T., Wang, C., Semla, T., Burk, M., Amuan, M. E., ... Berlowitz, D. R. (2011). Trends in use of high-risk medications for older veterans: 2004 to 2006. Journal of the American Geriatrics Society, 59(10), 1891-1898. https://doi.org/10.1111/j.1532-5415.2011.03559.x

Trends in use of high-risk medications for older veterans : 2004 to 2006. / Pugh, Mary Jo V; Hanlon, Joseph T.; Wang, Chen-pin; Semla, Todd; Burk, Muriel; Amuan, Megan E.; Lowery, Ashlei; Good, Chester B.; Berlowitz, Dan R.

In: Journal of the American Geriatrics Society, Vol. 59, No. 10, 10.2011, p. 1891-1898.

Research output: Contribution to journalArticle

Pugh, MJV, Hanlon, JT, Wang, C, Semla, T, Burk, M, Amuan, ME, Lowery, A, Good, CB & Berlowitz, DR 2011, 'Trends in use of high-risk medications for older veterans: 2004 to 2006', Journal of the American Geriatrics Society, vol. 59, no. 10, pp. 1891-1898. https://doi.org/10.1111/j.1532-5415.2011.03559.x
Pugh, Mary Jo V ; Hanlon, Joseph T. ; Wang, Chen-pin ; Semla, Todd ; Burk, Muriel ; Amuan, Megan E. ; Lowery, Ashlei ; Good, Chester B. ; Berlowitz, Dan R. / Trends in use of high-risk medications for older veterans : 2004 to 2006. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 10. pp. 1891-1898.
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