TY - JOUR
T1 - Trends in coronary artery disease mortality among hyperlipidemic patients
T2 - Geographic, gender, and racial insights from CDC WONDER data (1999–2020)
AU - Naveed, Muhammad Abdullah
AU - Neppala, Sivaram
AU - Chigurupati, Himaja Dutt
AU - Azeem, Bazil
AU - Ali, Ahila
AU - Ahmed, Faizan
AU - Zafar, Sabin
AU - Rehan, Muhammad Omer
AU - Iqbal, Rabia
AU - Mubeen, Manahil
AU - Abid, Hassaan
AU - Mubasher, Anum
AU - Paul, Timir
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/6
Y1 - 2025/6
N2 - Background: Coronary artery disease (CAD) in hyperlipidemia is a significant cause of mortality among adults in the United States. This study investigates trends in CAD-related mortality in hyperlipidemia among adults aged 25 and older, focusing on geographic, gender, and racial/ethnic disparities from 1999 to 2020. Methods: A retrospective analysis was conducted using the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) were calculated per 100,000 persons, stratified by year, sex, race/ethnicity, and geographical region. Results: Between 1999 and 2020, CAD in hyperlipidemia led to 407,667 deaths among US adults aged 25+. The AAMR for CAD in hyperlipidemia rose from 4.1 in 1999 to 12.1 in 2020, with an AAPC of 4.44 (95 % CI: 3.69 to 5.48, p < 0.000001). Men had higher AAMRs (12.4) than women (5.6), with significant increases for both sexes over time. Racial/ethnic disparities showed the highest AAMRs in Whites (8.9), followed by American Indians/Alaska Natives (8.6). Geographically, AAMRs varied from 3.8 in Alabama to 16.0 in Vermont, with the Midwest showing the highest rates (9.7). Nonmetropolitan areas exhibited higher AAMRs (9.6) than metropolitan areas (8.3), with a more significant increase in nonmetropolitan areas (AAPC: 5.82, p < 0.000001). Conclusion: This study highlights significant disparities in CAD in hyperlipidemia-related mortality among US adults by race, gender, and geography. The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.
AB - Background: Coronary artery disease (CAD) in hyperlipidemia is a significant cause of mortality among adults in the United States. This study investigates trends in CAD-related mortality in hyperlipidemia among adults aged 25 and older, focusing on geographic, gender, and racial/ethnic disparities from 1999 to 2020. Methods: A retrospective analysis was conducted using the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) were calculated per 100,000 persons, stratified by year, sex, race/ethnicity, and geographical region. Results: Between 1999 and 2020, CAD in hyperlipidemia led to 407,667 deaths among US adults aged 25+. The AAMR for CAD in hyperlipidemia rose from 4.1 in 1999 to 12.1 in 2020, with an AAPC of 4.44 (95 % CI: 3.69 to 5.48, p < 0.000001). Men had higher AAMRs (12.4) than women (5.6), with significant increases for both sexes over time. Racial/ethnic disparities showed the highest AAMRs in Whites (8.9), followed by American Indians/Alaska Natives (8.6). Geographically, AAMRs varied from 3.8 in Alabama to 16.0 in Vermont, with the Midwest showing the highest rates (9.7). Nonmetropolitan areas exhibited higher AAMRs (9.6) than metropolitan areas (8.3), with a more significant increase in nonmetropolitan areas (AAPC: 5.82, p < 0.000001). Conclusion: This study highlights significant disparities in CAD in hyperlipidemia-related mortality among US adults by race, gender, and geography. The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.
KW - Coronary artery disease
KW - Gender
KW - Geographics
KW - Hyperlipidemia
KW - Mortality
KW - Race
UR - https://www.scopus.com/pages/publications/105004238641
UR - https://www.scopus.com/inward/citedby.url?scp=105004238641&partnerID=8YFLogxK
U2 - 10.1016/j.ijcrp.2025.200416
DO - 10.1016/j.ijcrp.2025.200416
M3 - Article
C2 - 40475805
AN - SCOPUS:105004238641
SN - 2590-0862
VL - 25
JO - International Journal of Cardiology: Cardiovascular Risk and Prevention
JF - International Journal of Cardiology: Cardiovascular Risk and Prevention
M1 - 200416
ER -