Treatments of Depression and the Functional Capacity to Work

Jim Mintz, Lois Imber Mintz, Mary Jane Arruda, Sun Sook Hwang

Research output: Contribution to journalArticle

524 Scopus citations

Abstract

This study evaluated the effects of antidepressants and psychotherapy on work impairment in depressed patients. Original databases from 10 published treatment studies were compiled and analyzed (N=827). Functional work impairment was common at baseline, manifested by unemployment (11 %) or on-the-job performance problems (absenteeism, decreased productivity, interpersonal problems, 44%). Generally, work outcomes were good when treatment was symptomatically effective, but the trajectories of work restoration and symptom remission were different, with work recovery appearing to take considerably longer. Relapse was an important determinant of long-term occupational outcome, particularly for seriously ill patients for whom relapse meant rehospitalization or other profound social disruption. Affective impairment was distinguished from functional impairment, with the former characterizing milder depression and the latter characterizing moderate to severe depression. Some methodological recommendations are discussed.

Original languageEnglish (US)
Pages (from-to)761-768
Number of pages8
JournalArchives of General Psychiatry
Volume49
Issue number10
DOIs
StatePublished - Oct 1992
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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