Treatment options: Biological basis of regenerative endodontic procedures

Kenneth M. Hargreaves, Anibal Diogenes, Fabricio B. Teixeira

Research output: Contribution to journalArticlepeer-review

226 Scopus citations


Dental trauma occurs frequently in children and often can lead to pulpal necrosis. The occurrence of pulpal necrosis in the permanent but immature tooth represents a challenging clinical situation because the thin and often short roots increase the risk of subsequent fracture. Current approaches for treating the traumatized immature tooth with pulpal necrosis do not reliably achieve the desired clinical outcomes, consisting of healing of apical periodontitis, promotion of continued root development, and restoration of the functional competence of pulpal tissue. An optimal approach for treating the immature permanent tooth with a necrotic pulp would be to regenerate functional pulpal tissue. This review summarizes the current literature supporting a biological rationale for considering regenerative endodontic treatment procedures in treating the immature permanent tooth with pulp necrosis.

Original languageEnglish (US)
Pages (from-to)S30-S43
JournalJournal of endodontics
Issue number3 SUPPL.
StatePublished - Mar 2013
Externally publishedYes


  • Children
  • pulpal revascularization
  • regenerative endodontics
  • stem cells
  • trauma

ASJC Scopus subject areas

  • General Dentistry


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