Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill; Laura K. Najvar; Michael F. Luther; Annette W. Fothergill

doi:10.1128/aac.41.8.1775

Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill, Laura K. Najvar, Michael F. Luther, Annette W. Fothergill

Pathology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

Original language	English (US)
Pages (from-to)	1775-1777
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	41
Issue number	8
DOIs	https://doi.org/10.1128/aac.41.8.1775
State	Published - Aug 1997

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.",

author = "Graybill, {John R.} and Najvar, {Laura K.} and Luther, {Michael F.} and Fothergill, {Annette W.}",

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Treatment of murine disseminated candidiasis with L-743,872

Abstract

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