Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill; Laura K. Najvar; Michael F. Luther; Annette W. Fothergill

doi:10.1128/aac.41.8.1775

Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill, Laura K. Najvar, Michael F. Luther, Annette W. Fothergill

Pathology

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

Original language	English (US)
Pages (from-to)	1775-1777
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	41
Issue number	8
DOIs	https://doi.org/10.1128/aac.41.8.1775
State	Published - Aug 1997

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/aac.41.8.1775

Cite this

@article{4e6d30986b7d48a7a2a9018330edfacd,

title = "Treatment of murine disseminated candidiasis with L-743,872",

abstract = "L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.",

author = "Graybill, {John R.} and Najvar, {Laura K.} and Luther, {Michael F.} and Fothergill, {Annette W.}",

year = "1997",

month = aug,

doi = "10.1128/aac.41.8.1775",

language = "English (US)",

volume = "41",

pages = "1775--1777",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Treatment of murine disseminated candidiasis with L-743,872

AU - Graybill, John R.

AU - Najvar, Laura K.

AU - Luther, Michael F.

AU - Fothergill, Annette W.

PY - 1997/8

Y1 - 1997/8

N2 - L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

AB - L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

UR - http://www.scopus.com/inward/record.url?scp=0030743451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030743451&partnerID=8YFLogxK

U2 - 10.1128/aac.41.8.1775

DO - 10.1128/aac.41.8.1775

M3 - Article

C2 - 9257759

AN - SCOPUS:0030743451

VL - 41

SP - 1775

EP - 1777

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 8

ER -

Treatment of murine disseminated candidiasis with L-743,872

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this