Abstract
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1775-1777 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 41 |
| Issue number | 8 |
| State | Published - Aug 1 1997 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
Graybill, J. R., Najvar, L. K., Luther, M. F., & Fothergill, A. W. (1997). Treatment of murine disseminated candidiasis with L-743,872. Antimicrobial agents and chemotherapy, 41(8), 1775-1777.