Abstract
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
Original language | English (US) |
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Pages (from-to) | 1775-1777 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 41 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1997 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases