Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill, Laura K. Najvar, Michael F. Luther, Annette W. Fothergill

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

Original languageEnglish (US)
Pages (from-to)1775-1777
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number8
StatePublished - Aug 1997

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caspofungin
Candidiasis
Fluconazole
Candida albicans
Body Weight
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Graybill, J. R., Najvar, L. K., Luther, M. F., & Fothergill, A. W. (1997). Treatment of murine disseminated candidiasis with L-743,872. Antimicrobial Agents and Chemotherapy, 41(8), 1775-1777.

Treatment of murine disseminated candidiasis with L-743,872. / Graybill, John R.; Najvar, Laura K.; Luther, Michael F.; Fothergill, Annette W.

In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 8, 08.1997, p. 1775-1777.

Research output: Contribution to journalArticle

Graybill, JR, Najvar, LK, Luther, MF & Fothergill, AW 1997, 'Treatment of murine disseminated candidiasis with L-743,872', Antimicrobial Agents and Chemotherapy, vol. 41, no. 8, pp. 1775-1777.
Graybill JR, Najvar LK, Luther MF, Fothergill AW. Treatment of murine disseminated candidiasis with L-743,872. Antimicrobial Agents and Chemotherapy. 1997 Aug;41(8):1775-1777.
Graybill, John R. ; Najvar, Laura K. ; Luther, Michael F. ; Fothergill, Annette W. / Treatment of murine disseminated candidiasis with L-743,872. In: Antimicrobial Agents and Chemotherapy. 1997 ; Vol. 41, No. 8. pp. 1775-1777.
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