Treatment of murine disseminated candidiasis with L-743,872

John R. Graybill, Laura K. Najvar, Michael F. Luther, Annette W. Fothergill

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

Original languageEnglish (US)
Pages (from-to)1775-1777
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number8
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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