Abstract
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1775-1777 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 41 |
| Issue number | 8 |
| State | Published - Aug 1997 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Treatment of murine disseminated candidiasis with L-743,872. / Graybill, John R.; Najvar, Laura K.; Luther, Michael F.; Fothergill, Annette W.
In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 8, 08.1997, p. 1775-1777.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of murine disseminated candidiasis with L-743,872
AU - Graybill, John R.
AU - Najvar, Laura K.
AU - Luther, Michael F.
AU - Fothergill, Annette W.
PY - 1997/8
Y1 - 1997/8
N2 - L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
AB - L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030743451&partnerID=8YFLogxK
M3 - Article
VL - 41
SP - 1775
EP - 1777
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 8
ER -