Treatment of murine cryptococcal meningitis with UR-9751 and UR-9746

M. I. Restrepo, L. K. Najvar, F. Barchiesi, M. F. Luther, John R. Graybill

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In these studies, we compare the efficacy of two new azole antifungals with fluconazole in a murine model of cryptococcal meningitis. Mice were infected intracranially. Beginning one day later, groups of 7-10 mice were treated through to day 10 orally with UR-9751 or UR-9746 at 0.1, 0.25, 0.5, 1 or 10 mg kg-1 day-1 or fluconazole at 10 mg kg-1 day-1. At 10 mg kg-1 day-1, all three drugs prolonged survival over controls, but at 1 mg kg-1 day-1, only UR-9746 prolonged survival. Tissue counts were more varied on mice sacrificed 8 days after infection. In general, both UR drugs were equal or more potent than fluconazole, and UR-9751 was more effective than UR-9746.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalMedical mycology
Volume38
Issue number3
DOIs
StatePublished - Jun 2000

Keywords

  • Fluconazole
  • Murine cryptococcal meningitis

ASJC Scopus subject areas

  • Infectious Diseases

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