Treatment of murine cryptococcal meningitis with an SCH 39304-amphotericin B combination

M. M. Albert, J. R. Graybill, M. G. Rinaldi

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Cryptococcal meningitis was induced in BALB/c mice by intracerebral infection with Cryptococcus neoformans. Drug therapy was initiated 1 day later, with mice receiving amphotericin B (AMB), SCH 39304, combination therapy, or no drug therapy (controls). Most, but not all, combinations showed additive benefits, significantly prolonging survival and reducing organism counts in tissues compared with those in controls and groups which received the drugs independently. Optimum protection was obtained when a single dose of 10 mg of AMB per kg of body weight was combined with a fairly narrow SCH 39304 dose range. AMB antagonism did not occur with any regimen tested. AMB-azole combinations may be reasonable alternatives for patients who fail standard cryptococcosis therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)1721-1725
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume35
Issue number9
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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