TY - JOUR
T1 - Treatment of murine Candida krusei or Candida glabrata infection with L- 743,872
AU - Graybill, J. R.
AU - Bocanegra, R.
AU - Luther, M.
AU - Fothergill, A.
AU - Rinaldi, M. J.
PY - 1997/9
Y1 - 1997/9
N2 - L-743,872 is a broad-spectrum pneumocandin antifungal drug developed by Merck Research Co., and in the present work it was evaluated in vivo in murine models of Candida krusei and Candida glabrata infection. Mice were infected intravenously with two isolates of C. krusei and treated with fluconazole or L-743,872. Fluconazole was beneficial only in immune-competent mice infected with isolate 94-2696. At >0.5 mg/kg of body weight/day, L- 743,872 was effective against both infecting isolates in immune-competent and immune-suppressed mice. Against C. glabrata, L-743,872 was effective, at doses ≤0.5 mg/kg, in reducing fungal cell counts in the kidneys but not in the spleen. L-743,872 has significant potential for clinical development.
AB - L-743,872 is a broad-spectrum pneumocandin antifungal drug developed by Merck Research Co., and in the present work it was evaluated in vivo in murine models of Candida krusei and Candida glabrata infection. Mice were infected intravenously with two isolates of C. krusei and treated with fluconazole or L-743,872. Fluconazole was beneficial only in immune-competent mice infected with isolate 94-2696. At >0.5 mg/kg of body weight/day, L- 743,872 was effective against both infecting isolates in immune-competent and immune-suppressed mice. Against C. glabrata, L-743,872 was effective, at doses ≤0.5 mg/kg, in reducing fungal cell counts in the kidneys but not in the spleen. L-743,872 has significant potential for clinical development.
UR - http://www.scopus.com/inward/record.url?scp=0030832091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030832091&partnerID=8YFLogxK
U2 - 10.1128/aac.41.9.1937
DO - 10.1128/aac.41.9.1937
M3 - Article
C2 - 9303388
AN - SCOPUS:0030832091
VL - 41
SP - 1937
EP - 1939
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -