Treatment of hypothyroidism in infants, children and adolescents

Luisa Rodriguez, Catherine Dinauer, Gary Francis

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


In 2014, treatment guidelines from the American Thyroid Association reflected the general consensus that levothyroxine (LT4), adjusted to maintain a normal thyrotropin (TSH) level, is the preferred method for treatment of hypothyroidism. Although this is generally applicable to children, there are subsets of children for whom the diagnosis and treatment of hypothyroidism are problematic. These include children with congenital hypothyroidism (CH), low birth weight (LBW) and very low birth weight (VLBW), Down syndrome (DS), subclinical hypothyroidism, and obesity. In this Review, we focus on the progress and remaining pitfalls in diagnosis and treatment of hypothyroidism in these and other groups.

Original languageEnglish (US)
Pages (from-to)522-532
Number of pages11
JournalTrends in Endocrinology and Metabolism
Issue number7
StatePublished - Jul 2022


  • acquired
  • children
  • congenital
  • hypothyroidism
  • levothyroxine
  • therapy
  • triiodothyronine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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