Treatment of goodpasture's syndrome with plasmapheresis. A case report and review of the literature

Steven G. Rosenblatt, William Knight, George A. Bannayan, Curtis B. Wilson, Jay H. Stein

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

A case is reported of antiglomerular basement membrane antibody-induced Goodpasture's syndrome in which the patient required hemodialysis and was treated with immunosuppressive agents and plasmapheresis. A severe (80 per cent) crescentic lesion was reversed, and creatinine was stabilized at 2.5 mg/dl at one year follow-up. Earlier reports of therapy without plasmapheresis showed that 88 per cent of the patients would either die or require long-term hemodialysis. Fifteen other reported cases of Goodpasture's syndrome in which the patients were treated with plasmapheresis are reviewed. When reported, short-term follow-up showed that nine of these patients were alive without need of dialysis, five were receiving dialysis, and only two had died. This suggests that plasmapheresis and immunosuppressive therapy may reverse the renal lesion in some patients with Goodpasture's syndrome.

Original languageEnglish (US)
Pages (from-to)689-696
Number of pages8
JournalThe American Journal of Medicine
Volume66
Issue number4
DOIs
StatePublished - Apr 1979

ASJC Scopus subject areas

  • Medicine(all)

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