Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy

Antônio L. Teixeira, Débora P. Maia, Francisco Cardoso

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Serious adverse effects with antichoreic drugs can occur in patients with acute Sydenham's chorea (SC). The response to conventional treatment in severe SC may also be poor. Thus alternative therapeutic strategies have been developed. We report on four patients with severe acute SC (two with chorea paralytica and two with neuroleptic-induced parkinsonism) treated with i.v. methyl-prednisolone pulse-therapy followed by oral prednisone. The mean±SEM clinical rating score dropped from 63.7±10.2 to 33.5±10.6 in the first month post-treatment but in a lesser degree thereafter. Only one patient developed weight gain and 'moon facies'. This case series suggests that immune suppression with corticosteroids may be an effective and safe treatment in complicated and severe acute SC.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalParkinsonism and Related Disorders
Issue number5
StatePublished - Aug 2005
Externally publishedYes


  • Chorea
  • Corticosteroid
  • Methyl-prednisolone
  • Sydenham's chorea

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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