Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy

K. K. Hussein, S. Dahlberg, D. Head, C. C. Waddell, L. Dabich, J. Weick k., F. Morrison, J. H. Saiki, E. Metz, S. E. Rivkin, M. R. Grever, D. Boldt

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

The Southwest Oncology Group conducted a study of acute lymphoblastic leukemia (ALL) in adults over a 5-year period, testing the utility of the L-10M regimen initially described by the group from Memorial Sloan-Kettering Cancer Center. One hundred sixty-eight eligible patients were treated with this intensive combination chemotherapy regimen. One hundred fifteen (68%) achieved complete remission. With the current median follow-up time of 34.5 months, the median durations of remission, relapse-free survival, and overall survival were 22.9, 20.9, and 17.7 months, respectively. Only 35% of the patients over 50 years of age achieved a complete remission. Age was a significant prognostic factor for complete response, survival, relapse-free survival, and remission duration. In addition, a low initial WBC count was found to have a statistically significant association with longer remission duration. Responders between the ages of 20 and 49 years with WBC counts of < 15,000 appear to have an exceptionally good prognosis.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalBlood
Volume73
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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