TY - JOUR
T1 - Treating periodontal disease
T2 - from antimicrobials to immunomodulation
AU - Kobyra, Julie A.
AU - Shehabeldin, Mostafa
AU - Little, Steven R.
AU - Sfeir, Charles
N1 - Publisher Copyright:
© 2025
PY - 2026/1
Y1 - 2026/1
N2 - Dysregulated host immune responses are characteristic of a variety of inflammatory-mediated diseases. As such, novel immune-modulating therapies have been developed for the treatment of these inflammatory conditions. One condition that has seen a paradigm shift in therapeutic strategies is periodontal disease (PD), a common oral inflammatory condition. While initiated by bacteria, a dysregulated host immune response drives the disease. In this review, we discuss key innate and adaptive immune cells that have a role in PD progression, as well as different ways to target them. We highlight therapies that target dysregulated inflammatory pathways and their success in clinical trials. Lastly, we discuss the next steps for the clinical translation and subsequent adoption of these novel immunomodulatory treatments.
AB - Dysregulated host immune responses are characteristic of a variety of inflammatory-mediated diseases. As such, novel immune-modulating therapies have been developed for the treatment of these inflammatory conditions. One condition that has seen a paradigm shift in therapeutic strategies is periodontal disease (PD), a common oral inflammatory condition. While initiated by bacteria, a dysregulated host immune response drives the disease. In this review, we discuss key innate and adaptive immune cells that have a role in PD progression, as well as different ways to target them. We highlight therapies that target dysregulated inflammatory pathways and their success in clinical trials. Lastly, we discuss the next steps for the clinical translation and subsequent adoption of these novel immunomodulatory treatments.
KW - host immune response
KW - immunomodulation
KW - inflammatory condition
KW - periodontal disease
UR - https://www.scopus.com/pages/publications/105024365607
UR - https://www.scopus.com/pages/publications/105024365607#tab=citedBy
U2 - 10.1016/j.tips.2025.11.005
DO - 10.1016/j.tips.2025.11.005
M3 - Review article
C2 - 41372030
AN - SCOPUS:105024365607
SN - 0165-6147
VL - 47
SP - 40
EP - 52
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -