Treating epilepsy in the setting of medical comorbidities

Nivedita U. Jerath, Dronacharya Lamichhane, Madhu Jasti, Vinusha Yarlagadda, Eduardo Zilli, Yara Nazzal, Mark Granner

Research output: Contribution to journalReview articlepeer-review


Treatment of epilepsy in patients with medical comorbidities can be challenging. Comorbidities can affect medical management and quality of life. In this review, we discuss treatment options in patients with epilepsy and medical comorbidities. In our opinion, the best way to manage patients with medical comorbidities and epilepsy is to accurately recognize and diagnose medical comorbidities, and to have adequate knowledge and familiarity with antiepileptic drug (AED) metabolism, dosing, side effects, and drug interactions. We believe the trend should move toward using the newer generation of AEDs given their generally reduced rate of adverse effects and interactions. The primary goal of therapy is seizure freedom without side effects.

Original languageEnglish (US)
Article number298
JournalCurrent Treatment Options in Neurology
Issue number7
StatePublished - Jul 2014
Externally publishedYes


  • Coronary artery disease
  • Depression i migraine
  • Diabetes
  • Epilepsy
  • Hyperlipidemia
  • Kidney disease
  • Liver disease
  • Medical comorbidities
  • Nephrolithiasis
  • Obesity
  • Obstructive sleep apnea
  • Polycystic ovarian syndrome
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology


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