Treating epilepsy in the setting of medical comorbidities

Nivedita U. Jerath; Dronacharya Lamichhane; Madhu Jasti; Vinusha Yarlagadda; Eduardo Zilli; Yara Nazzal; Mark Granner

doi:10.1007/s11940-014-0298-1

Treating epilepsy in the setting of medical comorbidities

Nivedita U. Jerath, Dronacharya Lamichhane, Madhu Jasti, Vinusha Yarlagadda, Eduardo Zilli, Yara Nazzal, Mark Granner

Biggs Alzheimer's Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Treatment of epilepsy in patients with medical comorbidities can be challenging. Comorbidities can affect medical management and quality of life. In this review, we discuss treatment options in patients with epilepsy and medical comorbidities. In our opinion, the best way to manage patients with medical comorbidities and epilepsy is to accurately recognize and diagnose medical comorbidities, and to have adequate knowledge and familiarity with antiepileptic drug (AED) metabolism, dosing, side effects, and drug interactions. We believe the trend should move toward using the newer generation of AEDs given their generally reduced rate of adverse effects and interactions. The primary goal of therapy is seizure freedom without side effects.

Original language	English (US)
Article number	298
Journal	Current Treatment Options in Neurology
Volume	16
Issue number	7
DOIs	https://doi.org/10.1007/s11940-014-0298-1
State	Published - Jul 2014

Keywords

Coronary artery disease
Depression i migraine
Diabetes
Epilepsy
Hyperlipidemia
Kidney disease
Liver disease
Medical comorbidities
Nephrolithiasis
Obesity
Obstructive sleep apnea
Polycystic ovarian syndrome
Treatment

ASJC Scopus subject areas

Clinical Neurology

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title = "Treating epilepsy in the setting of medical comorbidities",

abstract = "Treatment of epilepsy in patients with medical comorbidities can be challenging. Comorbidities can affect medical management and quality of life. In this review, we discuss treatment options in patients with epilepsy and medical comorbidities. In our opinion, the best way to manage patients with medical comorbidities and epilepsy is to accurately recognize and diagnose medical comorbidities, and to have adequate knowledge and familiarity with antiepileptic drug (AED) metabolism, dosing, side effects, and drug interactions. We believe the trend should move toward using the newer generation of AEDs given their generally reduced rate of adverse effects and interactions. The primary goal of therapy is seizure freedom without side effects.",

keywords = "Coronary artery disease, Depression i migraine, Diabetes, Epilepsy, Hyperlipidemia, Kidney disease, Liver disease, Medical comorbidities, Nephrolithiasis, Obesity, Obstructive sleep apnea, Polycystic ovarian syndrome, Treatment",

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AU - Jerath, Nivedita U.

AU - Lamichhane, Dronacharya

AU - Jasti, Madhu

AU - Yarlagadda, Vinusha

AU - Zilli, Eduardo

AU - Nazzal, Yara

AU - Granner, Mark

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N2 - Treatment of epilepsy in patients with medical comorbidities can be challenging. Comorbidities can affect medical management and quality of life. In this review, we discuss treatment options in patients with epilepsy and medical comorbidities. In our opinion, the best way to manage patients with medical comorbidities and epilepsy is to accurately recognize and diagnose medical comorbidities, and to have adequate knowledge and familiarity with antiepileptic drug (AED) metabolism, dosing, side effects, and drug interactions. We believe the trend should move toward using the newer generation of AEDs given their generally reduced rate of adverse effects and interactions. The primary goal of therapy is seizure freedom without side effects.

AB - Treatment of epilepsy in patients with medical comorbidities can be challenging. Comorbidities can affect medical management and quality of life. In this review, we discuss treatment options in patients with epilepsy and medical comorbidities. In our opinion, the best way to manage patients with medical comorbidities and epilepsy is to accurately recognize and diagnose medical comorbidities, and to have adequate knowledge and familiarity with antiepileptic drug (AED) metabolism, dosing, side effects, and drug interactions. We believe the trend should move toward using the newer generation of AEDs given their generally reduced rate of adverse effects and interactions. The primary goal of therapy is seizure freedom without side effects.

KW - Coronary artery disease

KW - Depression i migraine

KW - Diabetes

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KW - Medical comorbidities

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KW - Obesity

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KW - Polycystic ovarian syndrome

KW - Treatment

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