Abstract
The survival, revascularization, reinnervation, and recovery of function of transplanted rat pineal glands were studied following grafting into four different locations in pinealectomized rats. Pineal grafts were well vascularized by fenestrated capillaries. Pinealocytes in the grafts maintained high-metabolic activity. More nerve fibers and terminals were observed in the grafts within the anterior chamber of the eye than in the third cerebral ventricle and the pineal region (in situ transplantation). No fibers or terminals were found in grafts placed beneath the renal capsule. Nighttime serum melatonin levels increased significantly in pinealectomized rats with transplants into either the third cerebral ventricle or the anterior eye chamber. This increase might reflect graft reinnervation. Yet day-night differences in serum melatonin were observed only in host rats receiving transplants in the anterior eye chamber. In conclusion, pinealocytes survived transplantation into different locations and exhibited ultrastructural features indicative of active secretory processes; however, day-night differences in serum melatonin are only restored following transplants into the anterior eye chamber. Reinnervation of the grafts by the host superior cervical ganglion is necessary for this restoration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 88-99 |
| Number of pages | 12 |
| Journal | Experimental Neurology |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1993 |
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ASJC Scopus subject areas
- Neurology
- Neuroscience(all)
Cite this
Transplantation of the Mammalian Pineal Gland : Studies of Survival, Revascularization, Reinnervation, and Recovery of Function. / Wu, Wutian; Scott, David E.; Reiter, Russel J.
In: Experimental Neurology, Vol. 122, No. 1, 07.1993, p. 88-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transplantation of the Mammalian Pineal Gland
T2 - Studies of Survival, Revascularization, Reinnervation, and Recovery of Function
AU - Wu, Wutian
AU - Scott, David E.
AU - Reiter, Russel J
PY - 1993/7
Y1 - 1993/7
N2 - The survival, revascularization, reinnervation, and recovery of function of transplanted rat pineal glands were studied following grafting into four different locations in pinealectomized rats. Pineal grafts were well vascularized by fenestrated capillaries. Pinealocytes in the grafts maintained high-metabolic activity. More nerve fibers and terminals were observed in the grafts within the anterior chamber of the eye than in the third cerebral ventricle and the pineal region (in situ transplantation). No fibers or terminals were found in grafts placed beneath the renal capsule. Nighttime serum melatonin levels increased significantly in pinealectomized rats with transplants into either the third cerebral ventricle or the anterior eye chamber. This increase might reflect graft reinnervation. Yet day-night differences in serum melatonin were observed only in host rats receiving transplants in the anterior eye chamber. In conclusion, pinealocytes survived transplantation into different locations and exhibited ultrastructural features indicative of active secretory processes; however, day-night differences in serum melatonin are only restored following transplants into the anterior eye chamber. Reinnervation of the grafts by the host superior cervical ganglion is necessary for this restoration.
AB - The survival, revascularization, reinnervation, and recovery of function of transplanted rat pineal glands were studied following grafting into four different locations in pinealectomized rats. Pineal grafts were well vascularized by fenestrated capillaries. Pinealocytes in the grafts maintained high-metabolic activity. More nerve fibers and terminals were observed in the grafts within the anterior chamber of the eye than in the third cerebral ventricle and the pineal region (in situ transplantation). No fibers or terminals were found in grafts placed beneath the renal capsule. Nighttime serum melatonin levels increased significantly in pinealectomized rats with transplants into either the third cerebral ventricle or the anterior eye chamber. This increase might reflect graft reinnervation. Yet day-night differences in serum melatonin were observed only in host rats receiving transplants in the anterior eye chamber. In conclusion, pinealocytes survived transplantation into different locations and exhibited ultrastructural features indicative of active secretory processes; however, day-night differences in serum melatonin are only restored following transplants into the anterior eye chamber. Reinnervation of the grafts by the host superior cervical ganglion is necessary for this restoration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027185939&partnerID=8YFLogxK
U2 - 10.1006/exnr.1993.1110
DO - 10.1006/exnr.1993.1110
M3 - Article
C2 - 8101823
AN - SCOPUS:0027185939
VL - 122
SP - 88
EP - 99
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -