TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS

Yair Reisner, Dahlia Kirkpatrick, Bo Dupont, Neena Kapoor, Marilyn S. Pollack, Robert A. Good, Richard J. O'Reilly

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

A new procedure for enrichment of marrow precursors and removal of T lymphocytes from large volumes of human bone marrow, involving initial differential agglutination of T lymphocytes and mature marrow elements with soybean agglutinin, followed by rosetting with sheep red blood cells, was used to fractionate marrow cells from an HLA-A, B, DR non-identical, MLC non-reactive, paternal donor for transplantation into an infant with acute leukaemia. This transplant became completely engrafted and resulted in full recovery of normal, donor-derived haematopoietic function without graft-versus-host disease, sustained for 11 weeks after transplantation, at-which time the patient's leukaemia recurred. Subsequently, the patient received chemotherapy and achieved a remission with regeneration of normal marrow cells of donor origin. The patient's course demonstrated the potential of lectin separated marrow grafts to restore durable haematopoiesis, without graft-versus-host disease, in a lethally irradiated allogeneic host.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalThe Lancet
Volume318
Issue number8242
DOIs
StatePublished - Aug 15 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS'. Together they form a unique fingerprint.

Cite this