Transnasal butorphanol and intramuscular meperidine in the treatment of postoperative pain

W. H. Schwesinger, J. C. Reynolds, D. H. Harshaw, L. A. Frakes

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In this double-blind, randomized, multicenter trial, 137 patients with moderate to severe postsurgical pain were randomly assigned to receive transnasal (TN) butorphanol 1 or 2 mg or intramuscular (IM) meperidine 37.5 or 75 mg. Measures of pain intensity, pain relief, pain half gone, and global assessments were tabulated at 5, 15, and 30 minutes and at 1, 1.5, 2, 3, 4, 5, and 6 hours after treatment. Time-effect curves for both pain relief and pain intensity differences through hour 2 showed comparable effects between 1-mg and 2-mg TN butorphanol doses and 37.5-mg and 75-mg IM meperidine doses, respectively. Transnasal butorphanol was equivalent in analgesic efficacy to equipotent doses of IM meperidine. There were no serious or unexpected adverse drug experiences or clinically significant changes in vital signs in any of the treatment groups. These results confirm that the transnasal administration of butorphanol in a 1- or 2-mg dose is rapid, safe, and effective in controlling postsurgical pain.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalAdvances in Therapy
Issue number3
StatePublished - 1992

ASJC Scopus subject areas

  • Pharmacology (medical)


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