Transluminal angioplasty evaluated by electron microscopy

C. L. Zollikofer, E. Salomonowitz, R. Sibley, J. Chain, W. F. Bruehlmann, W. R. Castaneda-Zuniga, K. Amplatz

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


To gain more understanding about the changes that follow balloon angioplasty, an electron and light microscopic study was carried out in normal canine arteries. Thirty-five arterial segments were dilated with balloon catheters. Early changes consisted of denudation of the intima with widespread necrosis of myocytes and dehiscence of collagen fibers. After 3 days, myocytes had disappeared leaving empty spaces and edematous ground substance. After 2 weeks, reendothelization occurred and there was evidence of intimal hyperplasia persisting up to 2 months. Repair of the dilated arterial segments occurred by proliferation of myocytes, formation of intima, and proliferation of collagen. In 2 to 3 months, repair of the intima and media was completed. After 6 months, dilated segments were characterized by persistent intimal hyperplasia and increased collagen content in the media.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
Issue number2
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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