To gain more understanding about the changes that follow balloon angioplasty, an electron and light microscopic study was carried out in normal canine arteries. Thirty-five arterial segments were dilated with balloon catheters. Early changes consisted of denudation of the intima with widespread necrosis of myocytes and dehiscence of collagen fibers. After 3 days, myocytes had disappeared leaving empty spaces and edematous ground substance. After 2 weeks, reendothelization occurred and there was evidence of intimal hyperplasia persisting up to 2 months. Repair of the dilated arterial segments occurred by proliferation of myocytes, formation of intima, and proliferation of collagen. In 2 to 3 months, repair of the intima and media was completed. After 6 months, dilated segments were characterized by persistent intimal hyperplasia and increased collagen content in the media.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging