TY - JOUR
T1 - Translational science in disinfection for regenerative endodontics
AU - Diogenes, Anibal R.
AU - Ruparel, Nikita B.
AU - Teixeira, Fabricio B.
AU - Hargreaves, Kenneth M.
PY - 2014/4
Y1 - 2014/4
N2 - The endodontic management of permanent immature teeth is fraught with challenges. Although treatment modalities for vital pulp therapy in these teeth provide long-term favorable outcome, the outcomes from the treatment of pulp necrosis and apical periodontitis are significantly less predictable. Immature teeth diagnosed with pulp necrosis have been traditionally treated with apexification or apexogenesis approaches. Unfortunately, these treatments provide little to no benefit in promoting continued root development. Regenerative endodontic procedures have emerged as an important alternative in treating teeth with otherwise questionable long-term prognosis because of thin, fragile dentinal walls and a lack of immunocompetency. These procedures rely heavily on root canal chemical disinfection of the root canal system. Traditionally, irrigants and medicaments have been chosen for their maximum antimicrobial effect without consideration for their effects on stem cells and the dentinal microenvironment. Translational research has been crucial to provide evidence for treatment modifications that aim to increase favorable outcome while steering away from common pitfalls in the currently used protocols. In this review, recent advances learned from translational research related to disinfection in regenerative endodontics are presented and discussed.
AB - The endodontic management of permanent immature teeth is fraught with challenges. Although treatment modalities for vital pulp therapy in these teeth provide long-term favorable outcome, the outcomes from the treatment of pulp necrosis and apical periodontitis are significantly less predictable. Immature teeth diagnosed with pulp necrosis have been traditionally treated with apexification or apexogenesis approaches. Unfortunately, these treatments provide little to no benefit in promoting continued root development. Regenerative endodontic procedures have emerged as an important alternative in treating teeth with otherwise questionable long-term prognosis because of thin, fragile dentinal walls and a lack of immunocompetency. These procedures rely heavily on root canal chemical disinfection of the root canal system. Traditionally, irrigants and medicaments have been chosen for their maximum antimicrobial effect without consideration for their effects on stem cells and the dentinal microenvironment. Translational research has been crucial to provide evidence for treatment modifications that aim to increase favorable outcome while steering away from common pitfalls in the currently used protocols. In this review, recent advances learned from translational research related to disinfection in regenerative endodontics are presented and discussed.
KW - Disinfection
KW - immature teeth
KW - mesenchymal adult stem cells
KW - pulp biology
KW - regenerative endodontics
KW - revascularization
KW - root canal disinfection
UR - http://www.scopus.com/inward/record.url?scp=84897553512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897553512&partnerID=8YFLogxK
U2 - 10.1016/j.joen.2014.01.015
DO - 10.1016/j.joen.2014.01.015
M3 - Article
C2 - 24698694
AN - SCOPUS:84897553512
SN - 0099-2399
VL - 40
SP - S52-S57
JO - Journal of endodontics
JF - Journal of endodontics
IS - 4 SUPPL.
ER -