Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form—Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire

Mihnea Alexandru Găman, Robyn Marie Scherber, Iulia Ursuleac, Ana Manuela Crişan, Sorina Nicoleta Bădeliţă, Bogdan Octavian Ionescu, Alexandra Elena Ghiaur, Melen Brînză, Nicoleta Pîrciulescu, Toma Octavian Lascăr, Camelia Cristina Diaconu, Amelia Maria Găman, Daniel Coriu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Patients with myeloproliferative neoplasms (MPNs) experience a high disease-related symptom burden. A specific instrument to evaluate quality of life (QoL), i.e., the MPN Symptom Assessment Form Total Symptom Score (MPN-SAF TSS; MPN-10), was developed. We conducted the translation, cultural adaptation, and validation into Romanian of the MPN-10. Methods: We translated the MPN-10 and tested its psychometric properties. Results: We recruited 180 MPN patients: 66 polycythemia vera (36.67%), 61 essential thrombocythemia (33.89%), 51 primary and secondary myelofibrosis (SMF) (28.33%), and 2 MPN-unclassifiable (1.11%). The mean TSS was 19.51 ± 16.51 points. Fatigue, inactivity, and concentration problems were the most cumbersome symptoms. We detected scoring differences between MPN subtypes regarding weight loss (p < 0.001), fatigue (p = 0.006), early satiety (p = 0.007), night sweats (p = 0.047), pruritus (p = 0.05), and TSS (p = 0.021). There were strong positive associations between TSS and inactivity, fatigue, and concentration problems, and moderate negative correlations between QoL scores and all MPN-10 items. Cronbach’s α internal consistency coefficient was 0.855. The Kaiser–Meyer–Olkin construct validity test result was 0.870 and the Bartlett Sphericity Test was significant (p < 0.001). Symptom scores were loaded into one single factor according to the exploratory factor analysis. Conclusions: The Romanian MPN-10 version displayed excellent psychometric properties and is a reliable instrument for assessing symptom burden and QoL in Romanian MPN patients.

Original languageEnglish (US)
Article number3284
JournalJournal of Clinical Medicine
Volume13
Issue number11
DOIs
StatePublished - Jun 2024
Externally publishedYes

Keywords

  • MPN Symptom Assessment Form
  • MPN-10
  • MPN-SAF
  • essential thrombocythemia
  • myelofibrosis
  • myeloproliferative neoplasms
  • patient-reported outcome measures
  • polycythemia vera
  • quality of life
  • symptom burden

ASJC Scopus subject areas

  • General Medicine

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