Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool

Jennifer E. Phipps, Taylor Hoyt, Thomas E. Milner, Marc D. Feldman

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Intravascular optical coherence tomography (IVOCT) continues to be a hot topic as a method for studying vulnerable plaque in research laboratories across the globe. It is also growing in popularity as a tool for interventional cardiologists to guide percutaneous coronary intervention (PCI). The power of IVOCT for diagnosis of thin-capped fibroatheromas (TCFAs) has yet to receive mainstream clinical attention due to the fact that clinicians still do not have a protocol to follow if TCFA are identified and that TCFA identification requires extensive training in IVOCT image analysis—it is not yet an automated process. In this review, we will discuss the progress of translation of IVOCT from predominantly a research tool to clinical practice by reviewing recent advances in the field of IVOCT for guiding PCI and how the challenge of automated plaque characterization for vulnerable plaque identification is being approached.

Original languageEnglish (US)
Article number30
JournalCurrent Cardiovascular Imaging Reports
Issue number8
StatePublished - Aug 17 2015


  • Atherosclerosis
  • Automation
  • Clinical translation
  • Intravascular optical coherence tomography
  • Plaque erosion
  • Quantitation
  • Spontaneous coronary artery dissection
  • Stent optimization
  • Vulnerable plaque

ASJC Scopus subject areas

  • Histology
  • Applied Microbiology and Biotechnology
  • Cell Biology


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