Background Portal vein thrombosis (PVT) develops in cirrhotic patients because of stagnation of blood flow. Transjugular intrahepatic portosystemic shunt (TIPS) creates a low-resistance conduit that restores portal venous patency and blood flow. Aim The effect of PVT on transplant-free survival in cirrhotic patients undergoing TIPS creation was evaluated. Patients and methods A multicenter, retrospective cohort study of patients who underwent TIPS creation for cirrhotic portal hypertension was carried out. A Cox model with propensity score adjustment was developed to evaluate the effect of PVT on 90-day and 3-year transplant-free survival. A subgroup analysis examining mortality of those with superior and inferior PVT was also carried out. Results A total of 252 consecutive TIPS creations were assessed, including 65 in patients with PVT. Survival of patients with high Model for End-stage Liver Disease scores (≥18) and PVT was not statistically different compared with patients with low Model for End-stage Liver Disease scores (<18) and no PVT at 90 days (P= 0.46) and 3 years (P=0.42). Those with superior PVT had improved 90-day and 3-year survival both compared with patients with a inferior PVT and those without a PVT (P <0.01, all cases). Conclusion The presence of PVT does not impair the prognosis of patients following TIPS creation, particularly in patients with superior portal occlusion.
|Original language||English (US)|
|Number of pages||8|
|Journal||European Journal of Gastroenterology and Hepatology|
|State||Published - Jan 1 2018|
- variceal bleeding
ASJC Scopus subject areas