Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans

Shenghui Wu, Joseph B. McCormick, Joanne E. Curran, Susan P. Fisher-Hoch

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes. Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5% and/or on hypoglycemic medication. Results: Ninety-six of 285 (33.7%) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81% (adjusted odds ratio [OR]: 1.81; 95% CI: 1.09-3.02). The risk of diabetes increased 8% for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95% CI: 1.05-1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9% (OR: 1.09; 95% CI: 1.003-1.18) compared with those who did not transition. Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management.

Original languageEnglish (US)
Pages (from-to)491-503
Number of pages13
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume10
DOIs
StatePublished - Dec 6 2017
Externally publishedYes

Fingerprint

Health
Odds Ratio
Glycosylated Hemoglobin A
LDL Lipoproteins
Hispanic Americans
Hypoglycemic Agents
Population
Weight Gain
Blood Glucose
Life Style
Fasting
Body Mass Index
Obesity
Hypertension

Keywords

  • Diabetes
  • Hispanic
  • Latino
  • Mexican-Americans
  • Pre-diabetes
  • Predictors
  • Risk
  • Transition

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology

Cite this

Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans. / Wu, Shenghui; McCormick, Joseph B.; Curran, Joanne E.; Fisher-Hoch, Susan P.

In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. 10, 06.12.2017, p. 491-503.

Research output: Contribution to journalArticle

Wu, Shenghui ; McCormick, Joseph B. ; Curran, Joanne E. ; Fisher-Hoch, Susan P. / Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans. In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2017 ; Vol. 10. pp. 491-503.
@article{18d02693abf642f1979a158f0a72ab77,
title = "Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans",
abstract = "Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes. Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5{\%} and/or on hypoglycemic medication. Results: Ninety-six of 285 (33.7{\%}) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81{\%} (adjusted odds ratio [OR]: 1.81; 95{\%} CI: 1.09-3.02). The risk of diabetes increased 8{\%} for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95{\%} CI: 1.05-1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9{\%} (OR: 1.09; 95{\%} CI: 1.003-1.18) compared with those who did not transition. Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management.",
keywords = "Diabetes, Hispanic, Latino, Mexican-Americans, Pre-diabetes, Predictors, Risk, Transition",
author = "Shenghui Wu and McCormick, {Joseph B.} and Curran, {Joanne E.} and Fisher-Hoch, {Susan P.}",
year = "2017",
month = "12",
day = "6",
doi = "10.2147/DMSO.S136368",
language = "English (US)",
volume = "10",
pages = "491--503",
journal = "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy",
issn = "1178-7007",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans

AU - Wu, Shenghui

AU - McCormick, Joseph B.

AU - Curran, Joanne E.

AU - Fisher-Hoch, Susan P.

PY - 2017/12/6

Y1 - 2017/12/6

N2 - Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes. Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5% and/or on hypoglycemic medication. Results: Ninety-six of 285 (33.7%) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81% (adjusted odds ratio [OR]: 1.81; 95% CI: 1.09-3.02). The risk of diabetes increased 8% for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95% CI: 1.05-1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9% (OR: 1.09; 95% CI: 1.003-1.18) compared with those who did not transition. Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management.

AB - Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes. Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5% and/or on hypoglycemic medication. Results: Ninety-six of 285 (33.7%) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81% (adjusted odds ratio [OR]: 1.81; 95% CI: 1.09-3.02). The risk of diabetes increased 8% for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95% CI: 1.05-1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9% (OR: 1.09; 95% CI: 1.003-1.18) compared with those who did not transition. Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management.

KW - Diabetes

KW - Hispanic

KW - Latino

KW - Mexican-Americans

KW - Pre-diabetes

KW - Predictors

KW - Risk

KW - Transition

UR - http://www.scopus.com/inward/record.url?scp=85037815494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037815494&partnerID=8YFLogxK

U2 - 10.2147/DMSO.S136368

DO - 10.2147/DMSO.S136368

M3 - Article

VL - 10

SP - 491

EP - 503

JO - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

JF - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

SN - 1178-7007

ER -