Transgenic mouse models of hormonal mammary carcinogenesis: Advantages and limitations

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Mouse models of breast cancer, especially transgenic and knockout mice, have been established as valuable tools in shedding light on factors involved in preneoplastic changes, tumor development and malignant progression. The majority of mouse transgenic models develop estrogen receptor (ER) negative tumors. This is seen as a drawback because the majority of human breast cancers present an ER positive phenotype. On the other hand, several transgenic mouse models have been developed that produce ER positive mammary tumors. These include mice over-expressing aromatase, ERα, PELP-1 and AIB-1. In this review, we will discuss the value of these models as physiologically relevant in vivo systems to understand breast cancer as well as some of the pitfalls involving these models. In all, we argue that the use of transgenic models has improved our understanding of the molecular aspects and biology of breast cancer. Article from the Special issue on Steroids and cancer.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume131
Issue number3-5
DOIs
StatePublished - Sep 1 2012

Keywords

  • Breast cancer
  • Hormone-mediated cancer models
  • Hormones and cancer
  • Transgenic models

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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