Abstract
A patient with von Willebrand's disease was transfused with a small amount of fresh frozen plasma. Factor VIII coagulant activity reached a peak at the 6th hour after transfusion whereas the factor VIII-related antigen peaked at the 3rd hour and started to decline rapidly. The ristocetin-Willebrand factor rose immediately after the transfusion to a level which would have been predicted from the amount of this activity transfused and remained at levels slightly lower than this for the remainder of the study. Transfusion of the patient's own plasma obtained at the height of the factor VIII response produced no increase in any of the activities measured. Factor VIII stimulated by transfusion is more labile in vitro than normal Factor VIII.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 479-494 |
| Number of pages | 16 |
| Journal | Thrombosis Research |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology
Cite this
Transfusion and autotransfusion of plasma in von Willebrand's disease. / Bowie, E. J W; Fass, D. N.; Olson, John D.
In: Thrombosis Research, Vol. 5, No. 4, 1974, p. 479-494.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transfusion and autotransfusion of plasma in von Willebrand's disease
AU - Bowie, E. J W
AU - Fass, D. N.
AU - Olson, John D
PY - 1974
Y1 - 1974
N2 - A patient with von Willebrand's disease was transfused with a small amount of fresh frozen plasma. Factor VIII coagulant activity reached a peak at the 6th hour after transfusion whereas the factor VIII-related antigen peaked at the 3rd hour and started to decline rapidly. The ristocetin-Willebrand factor rose immediately after the transfusion to a level which would have been predicted from the amount of this activity transfused and remained at levels slightly lower than this for the remainder of the study. Transfusion of the patient's own plasma obtained at the height of the factor VIII response produced no increase in any of the activities measured. Factor VIII stimulated by transfusion is more labile in vitro than normal Factor VIII.
AB - A patient with von Willebrand's disease was transfused with a small amount of fresh frozen plasma. Factor VIII coagulant activity reached a peak at the 6th hour after transfusion whereas the factor VIII-related antigen peaked at the 3rd hour and started to decline rapidly. The ristocetin-Willebrand factor rose immediately after the transfusion to a level which would have been predicted from the amount of this activity transfused and remained at levels slightly lower than this for the remainder of the study. Transfusion of the patient's own plasma obtained at the height of the factor VIII response produced no increase in any of the activities measured. Factor VIII stimulated by transfusion is more labile in vitro than normal Factor VIII.
UR - http://www.scopus.com/inward/record.url?scp=0016287867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016287867&partnerID=8YFLogxK
U2 - 10.1016/0049-3848(74)90005-X
DO - 10.1016/0049-3848(74)90005-X
M3 - Article
AN - SCOPUS:0016287867
VL - 5
SP - 479
EP - 494
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 4
ER -