TY - JOUR
T1 - Transforming growth factor-beta
T2 - A clinical target for the treatment of diabetic nephropathy
AU - McGowan, Tracy A.
AU - Zhu, Yanqing
AU - Sharma, Kumar
N1 - Funding Information:
This review was supported in part with funding from National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK63017) to KS and TAM.
PY - 2004/12
Y1 - 2004/12
N2 - Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming grcmdh factor-β (TGF-β) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies have not only demonstrated the beneficial effects of blocking TGF-β on matrix accumulation but have also found that blocking TGF-β may have important hemodynamic effects that are relevant to diabetic complications. In this article, we review the latest knowledge regarding the role of TGF-β in diabetic kidney disease and discuss available and novel therapeutic approaches. The role of a novel antifibrotic drug, pirfenidone, may have important clinical relevance to diabetic nephropathy.
AB - Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming grcmdh factor-β (TGF-β) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies have not only demonstrated the beneficial effects of blocking TGF-β on matrix accumulation but have also found that blocking TGF-β may have important hemodynamic effects that are relevant to diabetic complications. In this article, we review the latest knowledge regarding the role of TGF-β in diabetic kidney disease and discuss available and novel therapeutic approaches. The role of a novel antifibrotic drug, pirfenidone, may have important clinical relevance to diabetic nephropathy.
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U2 - 10.1007/s11892-004-0055-z
DO - 10.1007/s11892-004-0055-z
M3 - Review article
C2 - 15539010
AN - SCOPUS:12144264716
SN - 1534-4827
VL - 4
SP - 447
EP - 454
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 6
ER -