Transforming growth factor-β1 in carcinogenesis, progression, and therapy in cervical cancer

Haiyan Zhu, Hui Luo, Zhaojun Shen, Xiaoli Hu, Luzhe Sun, Xueqiong Zhu

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays important roles in cervical tumor formation, invasion, progression, and metastasis. TGF-β1 functions as a tumor inhibitor in precancerous lesions and early stage cancers of cervix whereas as a tumor promoter in later stage. This switch from a tumor inhibitor to a tumor promoter might be due to various alterations in TGF-β signaling pathway, such as mutations or loss of expression of TGF-β receptors and SMAD proteins. Additionally, the oncoproteins of human papillomaviruses have been shown to stimulate TGF-β1 expression, which in turn suppresses host immune surveillance. Thus, in addition to driving tumor cell migration and metastasis, TGF-β1 is believed to play a key role in promoting human papillomavirus infection by weakening host immune defense. In this article, we will discuss the role of TGF-β1 in the expression, carcinogenesis, progression, and therapy in cervical cancers. A better understanding of this cytokine in cervical carcinogenesis is essential for critical evaluation of this cytokine as a potential prognostic marker and therapeutic target.

Original languageEnglish (US)
Pages (from-to)7075-7083
Number of pages9
JournalTumor Biology
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Cervical cancers
  • TGF-β1
  • Tumor promotion
  • Tumor suppression

ASJC Scopus subject areas

  • Cancer Research

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