Transforming growth factor-β signaling is constantly shaping memory T-cell population

Chaoyu Ma, Nu Zhang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The long-term maintenance of memory T cells is essential for successful vaccines. Both the quantity and the quality of the memory T-cell population must be maintained. The signals that control the maintenance of memory T cells remain incompletely identified. Here we used two genetic models to show that continuous transforming growth factor-β signaling to antigen-specific T cells is required for the differentiation and maintenance of memory CD8+ T cells. In addition, both infection-induced and microbiota-induced inflammation impact the phenotypic and functional identity of memory CD8+ T cells.

Original languageEnglish (US)
Pages (from-to)11013-11017
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number35
DOIs
StatePublished - Sep 1 2015

Keywords

  • Acute infection
  • CD8
  • Memory T cell
  • TGF-β

ASJC Scopus subject areas

  • General

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