Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

Nu Zhang, Michael J. Bevan

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Tissue-resident memory T (Trm) cells represent a population of memory CD8+ Tcells that can act as first responders to local infection. The mechanisms regulating the formation and maintenance of intestinal Trm cells remain elusive. Here we showed that transforming growth factor-β (TGF-β) controlled both stages of gut Trm cell differentiation through different mechanisms. During the formation phase of Trm cells, TGF-β signaling inhibited the migration of effector CD8+ Tcells from the spleen to the gut by dampening the expression of integrin α4β7. During the maintenance phase, TGF-β was required for the retention of intestinal Trm cells at least in part through the induction of integrins αEβ7 and α1, as well as CD69. Thus, the cytokine acts to control cytotoxic Tcell differentiation in lymphoid and peripheral organs.

Original languageEnglish (US)
Pages (from-to)687-696
Number of pages10
JournalImmunity
Volume39
Issue number4
DOIs
StatePublished - Oct 17 2013

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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