Transforming growth factor α distribution in rectal crypts as a bidmarker of decreased colon cancer risk in patients consuming cellulose

W. Elaine Hardman, Ivan L. Cameron, William H. Beer, K. Vincent Speeg, Shailesh C. Kadakia, Kevin A. Lang

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Data from rat experimental carcinogenesis studies indicate that supplemental dietary cellulose reduces the incidence of colon cancer. Epidemiology studies also indicate that high dietary fiber reduces the risk of colorectal cancer in humans. Patients diagnosed with sporadic adenomas were entered into a randomized clinical trial to determine if supplemental dietary cellulose would reduce the patients' risk for colon cancer. Immunohistochemical staining for transforming growth factor α (TGF-α) was done on biopsies of rectal mucosa taken from patients at the time of initial polypectomy and 1 year later. Results were evaluated for utility as a surrogate end point biomarker for reduction in colon cancer risk. There was a significant decrease in the fraction of the rectal crypt cells that stained for TGF-α in six of seven of the patients given the cellulose supplements but in only one of six of the patients not given cellulose. Thus, whether evaluated as a group or in individual patients, there was a significant decrease in TGF-α in rectal crypts due to cellulose intervention, which correlated with the expected ability of supplemental dietary cellulose to decrease the risk for colon cancer. Long-term testing of the ability of dietary cellulose to reduce adenoma recurrence is under way to validate the use of TGF-α as a surrogate end point biomarker.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume6
Issue number8
Publication statusPublished - Aug 26 1997

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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