Transcriptional regulation and chromatin dynamics at DNA double-strand breaks

Sunwoo Min, Jae Hoon Ji, Yungyeong Heo, Hyeseong Cho

Research output: Contribution to journalReview articlepeer-review

Abstract

In eukaryotic cells, DNA damage can occur at any time and at any chromatin locus, including loci at which active transcription is taking place. DNA double-strand breaks affect chromatin integrity and elicit a DNA damage response to facilitate repair of the DNA lesion. Actively transcribed genes near DNA lesions are transiently suppressed by crosstalk between DNA damage response factors and polycomb repressive complexes. Epigenetic modulation of the chromatin environment also contributes to efficient DNA damage response signaling and transcriptional repression. On the other hand, RNA transcripts produced in the G1 phase, as well as the active chromatin context of the lesion, appear to drive homologous recombination repair. Here, we discuss how the ISWI family of chromatin remodeling factors coordinates the DNA damage response and transcriptional repression, especially in transcriptionally active regions, highlighting the direct modulation of the epigenetic environment.

Original languageEnglish (US)
Pages (from-to)1705-1712
Number of pages8
JournalExperimental and Molecular Medicine
Volume54
Issue number10
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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