Transcriptional and post-translational regulation of adiponectin

Meilian Liu, Feng Liu

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Adiponectin is an adipose-tissue-derived hormone with antidiabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalBiochemical Journal
Volume425
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Adiponectin
Insulin Resistance
Obesity
Insulin
Molecular mass
Transcription
Medical problems
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Adipose Tissue
Homeostasis
Anti-Inflammatory Agents
Genes
Hormones
Tissue
Serum

Keywords

  • Adiponectin
  • Dsb
  • Endoplasmic reticulum stress
  • Inflammation
  • Insulin
  • Peroxisome-proliferator-activated receptor γ (PPARγ)
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Transcriptional and post-translational regulation of adiponectin. / Liu, Meilian; Liu, Feng.

In: Biochemical Journal, Vol. 425, No. 1, 01.01.2010, p. 41-52.

Research output: Contribution to journalArticle

@article{9dd458d43ae84c668b12858e05e0f1e7,
title = "Transcriptional and post-translational regulation of adiponectin",
abstract = "Adiponectin is an adipose-tissue-derived hormone with antidiabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.",
keywords = "Adiponectin, Dsb, Endoplasmic reticulum stress, Inflammation, Insulin, Peroxisome-proliferator-activated receptor γ (PPARγ), Transcription factor",
author = "Meilian Liu and Feng Liu",
year = "2010",
month = "1",
day = "1",
doi = "10.1042/BJ20091045",
language = "English (US)",
volume = "425",
pages = "41--52",
journal = "Biochemical Journal",
issn = "0264-6021",
publisher = "Portland Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Transcriptional and post-translational regulation of adiponectin

AU - Liu, Meilian

AU - Liu, Feng

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Adiponectin is an adipose-tissue-derived hormone with antidiabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.

AB - Adiponectin is an adipose-tissue-derived hormone with antidiabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.

KW - Adiponectin

KW - Dsb

KW - Endoplasmic reticulum stress

KW - Inflammation

KW - Insulin

KW - Peroxisome-proliferator-activated receptor γ (PPARγ)

KW - Transcription factor

UR - http://www.scopus.com/inward/record.url?scp=72449141637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72449141637&partnerID=8YFLogxK

U2 - 10.1042/BJ20091045

DO - 10.1042/BJ20091045

M3 - Article

C2 - 20001961

AN - SCOPUS:72449141637

VL - 425

SP - 41

EP - 52

JO - Biochemical Journal

JF - Biochemical Journal

SN - 0264-6021

IS - 1

ER -