Transcriptional and post-translational regulation of adiponectin

Meilian Liu, Feng Liu

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations

Abstract

Adiponectin is an adipose-tissue-derived hormone with antidiabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalBiochemical Journal
Volume425
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Adiponectin
  • Dsb
  • Endoplasmic reticulum stress
  • Inflammation
  • Insulin
  • Peroxisome-proliferator-activated receptor γ (PPARγ)
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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