Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)

M. Paulose-Murphy; N. K. Ha; C. Xiang; Y. Chen; L. Gillim; R. Yarchoan; P. Meltzer; M. Bittner; J. Trent; S. Zeichner

doi:10.1128/JVI.75.10.4843-4853.2001

Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)

M. Paulose-Murphy, N. K. Ha, C. Xiang, Y. Chen, L. Gillim, R. Yarchoan, P. Meltzer, M. Bittner, J. Trent, S. Zeichner

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV.8.

Original language	English (US)
Pages (from-to)	4843-4853
Number of pages	11
Journal	Journal of virology
Volume	75
Issue number	10
DOIs	https://doi.org/10.1128/JVI.75.10.4843-4853.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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abstract = "Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV.8.",

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AU - Paulose-Murphy, M.

AU - Ha, N. K.

AU - Xiang, C.

AU - Chen, Y.

AU - Gillim, L.

AU - Yarchoan, R.

AU - Meltzer, P.

AU - Bittner, M.

AU - Trent, J.

AU - Zeichner, S.

PY - 2001

Y1 - 2001

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AB - Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV.8.

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Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)

Abstract

ASJC Scopus subject areas

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