Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas; Leanne Embry; Karin Walsh; Kim Bull; Richard Grundy; Colin Kennedy; Jurgen Lemiere; Pablo Hernáiz Driever; Jennifer Limond; Mathilde Chevignard; Kristina Hardy

doi:10.1002/pbc.30171

Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas, Leanne Embry, Karin Walsh, Kim Bull, Richard Grundy, Colin Kennedy, Jurgen Lemiere, Pablo Hernáiz Driever, Jennifer Limond, Mathilde Chevignard, Kristina Hardy

Division of Hematology-Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

Original language	English (US)
Article number	e30171
Journal	Pediatric Blood and Cancer
Volume	70
Issue number	5
DOIs	https://doi.org/10.1002/pbc.30171
State	Published - May 2023

Keywords

brain tumour
cancer
child
cognitive
late effects
paediatric
quality of survival

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.30171

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title = "Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials",

abstract = "The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.",

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language = "English (US)",

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T1 - Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

AU - Thomas, Sophie

AU - Embry, Leanne

AU - Walsh, Karin

AU - Bull, Kim

AU - Grundy, Richard

AU - Kennedy, Colin

AU - Lemiere, Jurgen

AU - Hernáiz Driever, Pablo

AU - Limond, Jennifer

AU - Chevignard, Mathilde

AU - Hardy, Kristina

PY - 2023/5

Y1 - 2023/5

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AB - The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

KW - brain tumour

KW - cancer

KW - child

KW - cognitive

KW - late effects

KW - paediatric

KW - quality of survival

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JO - Pediatric Blood and Cancer

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ER -

Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Abstract

Keywords

ASJC Scopus subject areas

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